Human cytomegalovirus vaccine development: Immune responses to look into vaccine strategy

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Immune Responses and Vaccine Development for Cytomegalovirus Infections

Aims: (1) To review the published literature on immune biology of hostCytomegavovirus (CMV) interactions and to discuss the host immune responses against viral infection, providing insights into the complex interplay between the host and the virus that facilitates viral persistence. (2) To report on the status of CMV vaccines that are currently in preclinical and clinical development, outlining...

متن کامل

Human immune responses to Schistosoma mansoni vaccine candidate antigens.

To determine the naturally occurring immunological responses to the Schistosoma mansoni antigens paramyosin, IrV-5, Sm-23 (MAP-3), and triose phosphate isomerase (MAP-4), a total of 119 subjects from an area of endemicity for schistosomiasis, including "resistant" subjects (n = 17) were evaluated. Specific immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, and IgA levels for each of the antigens and t...

متن کامل

Immune responses to hepatitis B vaccine.

chronic carriers worldwide.1 The highest carrier rate is in Asia and Africa. 2 Chronic infection develops among 90% of newborns, 29-40% of children and 5-10% of adults.3 Patients with long-standing active liver disease are at high risk of developing liver cirrhosis and hepatocellular carcinoma.4 Hepatitis B virus is responsible for 80% of liver cancer cases in the world.5 Therefore, prevention ...

متن کامل

The pentameric complex of human Cytomegalovirus: cell tropism, virus dissemination, immune response and vaccine development.

Between the 1980s and 1990s, three assays were developed for diagnosis of human cytomegalovirus (HCMV) infections: leuko (L)-antigenemia, l-viremia and l-DNAemia, detecting viral protein pp65, infectious virus and viral DNA, respectively, in circulating leukocytes Repeated initial attempts to reproduce the three assays in vitro using laboratory-adapted strains and infected cell cultures were co...

متن کامل

Immune monitoring of T-cell responses in cancer vaccine development.

Monitoring cellular immune responses is one prerequisite for rational development of cancer vaccines. The primary objective of immune monitoring is to determine the efficacy of a vaccine to induce or augment a specific T-cell response. Further questions relate to the prevalence and functional relevance of spontaneous tumor-directed immune responses, the functional characteristics of T-cell resp...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Human Vaccines & Immunotherapeutics

سال: 2017

ISSN: 2164-5515,2164-554X

DOI: 10.1080/21645515.2017.1391433